東北大学病院高度救命救急センター　東北大学大学院医学系研究科 外科病態学講座 救急医学分野

研究

業績 2025年

学会発表や講演、著書・論文など、これまでの業績を掲載してあります。

論文・著書

論文

  1. "Utility of sepsis-induced coagulopathy among disseminated intravascular coagulation diagnostic criteria: A multicenter retrospective validation study"
  2. Bronchiolitis obliterans due to toxic epidermal necrolysis with structural evaluation using computed tomography bronchography: A case report"
  3. Kobayashi E, Shiraishi A, Karumai T, Hayashi Y, Abe T, Ogura H, Shigeki K, Gando S, Okamoto K, Umemura Y, Sasaki J, Shiino Y, Mayumi T. Carbapenem Usage in the Initial Antibiotic Therapy of Sepsis in Japanese Intensive Care Units. Cureus. 2025 Jan 11;17(1):e77271. doi: 10.7759/cureus.77271. PMID: 39931585; PMCID: PMC11809119.
  4. Gando S, Wada T, Yamakawa K, Abe T, Fujishima S, Kushimoto S, Mayumi T, Ogura H, Saitoh D, Shiraishi A, Umemura Y, Otomo Y. Utility of sepsis-induced coagulopathy among disseminated intravascular coagulation diagnostic criteria: A multicenter retrospective validation study. Thromb Haemost. 2025 Feb 3. doi: 10.1055/a-2530-7553. Epub ahead of print. PMID: 39900104.
  5. Hayakawa M, Seki Y, Ikezoe T, Yamakawa K, Okamoto K, Kushimoto S, Sakamoto Y, Itagaki Y, Takahashi Y, Ishikura H, Mayumi T, Tamura T, Nishio K, Kawazoe Y, Shigeno A, Takatani Y, Tampo A, Nakamura Y, Mochizuki K, Yada N, Kawasaki K, Kiyokawa A, Morikawa M, Uchiba M, Matsumoto T, Asakura H, Madoiwa S, Uchiyama T, Yamada S, Koga S, Ito T, Iba T, Kawano N, Gando S, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis, Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4-trauma, burn, obstetrics, acute pancreatitis/liver failure, and others. Int J Hematol. 2025 Jan 31. doi: 10.1007/s12185-025-03918-0. Epub ahead of print. PMID: 39890756.
  6. Ohbe H, Kudo D, Kimura Y, Matsui H, Yasunaga H, Kushimoto S. In-hospital mortality of patients admitted to the intermediate care unit in hospitals with and without an intensive care unit: a nationwide inpatient database study. Crit Care. 2025 Jan 20;29(1):34. doi: 10.1186/s13054-025-05275-0. PMID: 39833886; PMCID: PMC11744974.
  7. Seki Y, Okamoto K, Ikezoe T, Yamakawa K, Madoiwa S, Uchiyama T, Asakura H, Yamada S, Koga S, Ishikura H, Ito T, Iba T, Uchiba M, Kawasaki K, Kawano N, Gando S, Kushimoto S,
    Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Mayumi T, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 3: solid cancers and vascular abnormalities. Int J Hematol. 2025 Jan 10. doi: 10.1007/s12185-024-03912-y. Epub ahead of print. PMID: 39792236.
  8. Yamamoto R, Sato Y, Maeshima K, Tomita K, Takemura R, Katsura M, Kondo Y, Yasuda H, Kushimoto S, Sasaki J. Pediatric blunt liver and spleen injury treated in hospitals with pediatric intensive care units: Post-hoc analysis of a multicenter, retrospective observational study. J Pediatr Surg. 2024 Dec 16;60(3):162106. doi: 10.1016/j.jpedsurg.2024.162106. Epub ahead of print. PMID: 39733604.
  9. Yamakawa K, Okamoto K, Seki Y, Ikezoe T, Ito T, Iba T, Gando S, Ushio N, Totoki T, Wada T, Asakura H, Ishikura H, Uchiba M, Uchiyama T, Kawasaki K, Kawano N, Kushimoto S, Koga S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Madoiwa S, Mayumi T, Yamada S, Wada H; Committee of the Clinical Practice Guidelines for Management of Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis. Int J Hematol. 2024 Dec 16. doi: 10.1007/s12185-024-03896-9. Epub ahead of print. PMID: 39676120.
  10. Kawano N, Ikezoe T, Seki Y, Yamakawa K, Okamoto K, Fukatsu M, Madoiwa S, Uchiyama T, Asakura H, Yamada S, Koga S, Ishikura H, Ito T, Iba T, Uchiba M, Kawasaki K, Gando S, Kushimoto S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Mayumi T, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 2: hematologic malignancy. Int J Hematol. 2024 Dec 15. doi: 10.1007/s12185-024-03887-w. Epub ahead of print. PMID: 39674834.
  11. 勝田　賢, 工藤大介, 久志本成樹. ARDS. ER･ICUの適正輸液. メジカルビュー社. 東京. 2025. Pp188-193.
  12. 藤田　基生, 久志本成樹. 脳死下臓器提供を目的とする転院搬送に向けた三次医療圏体制整備. 日外科系連会誌. 2025; 50: 78-81
  13. Shime N, Nakada TA, Yatabe T, Yamakawa K, Aoki Y, Inoue S, Iba T, Ogura H, Kawai Y, Kawaguchi A, Kawasaki T, Kondo Y, Sakuraya M, Taito S, Doi K, Hashimoto H, Hara Y, Fukuda T, Matsushima A, Egi M, Kushimoto S, Oami T, Kikutani K, Kotani Y, Aikawa G, Aoki M, Akatsuka M, Asai H, Abe T, Amemiya Y, Ishizawa R, Ishihara T, Ishimaru T, Itosu Y, Inoue H, Imahase H, Imura H, Iwasaki N, Ushio N, Uchida M, Uchi M, Umegaki T, Umemura Y, Endo A, Oi M, Ouchi A, Osawa I, Oshima Y, Ota K, Ohno T, Okada Y, Okano H, Ogawa Y, Kashiura M, Kasugai D, Kano KI, Kamidani R, Kawauchi A, Kawakami S, Kawakami D, Kawamura Y, Kandori K, Kishihara Y, Kimura S, Kubo K, Kuribara T, Koami H, Koba S, Sato T, Sato R, Sawada Y, Shida H, Shimada T, Shimizu M, Shimizu K, Shiraishi T, Shinkai T, Tampo A, Sugiura G, Sugimoto K, Sugimoto H, Suhara T, Sekino M, Sonota K, Taito M, Takahashi N, Takeshita J, Takeda C, Tatsuno J, Tanaka A, Tani M, Tanikawa A, Chen H, Tsuchida T, Tsutsumi Y, Tsunemitsu T, Deguchi R, Tetsuhara K, Terayama T, Togami Y, Totoki T, Tomoda Y, Nakao S, Nagasawa H, Nakatani Y, Nakanishi N, Nishioka N, Nishikimi M, Noguchi S, Nonami S, Nomura O, Hashimoto K, Hatakeyama J, Hamai Y, Hikone M, Hisamune R, Hirose T, Fuke R, Fujii R, Fujie N, Fujinaga J, Fujinami Y, Fujiwara S, Funakoshi H, Homma K, Makino Y, Matsuura H, Matsuoka A, Matsuoka T, Matsumura Y, Mizuno A, Miyamoto S, Miyoshi Y, Murata S, Murata T, Yakushiji H, Yasuo S, Yamada K, Yamada H, Yamamoto R, Yamamoto R, Yumoto T, Yoshida Y, Yoshihiro S, Yoshimura S, Yoshimura J, Yonekura H, Wakabayashi Y, Wada T, Watanabe S, Ijiri A, Ugata K, Uda S, Onodera R, Takahashi M, Nakajima S, Honda J, Matsumoto T. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024. Acute Med Surg. 2025 Feb 24;12(1):e70037. doi: 10.1002/ams2.70037. PMID: 39996161; PMCID: PMC11848044.
  14. 横山龍人, 工藤大介, 中田貴史, 水戸部慶彦, 久志本成樹. COVID–19を契機に発症したと考えられるシェーグレン症候群に伴う尿細管性アシドーシスの1例. 日救医会誌. 2025;36(3):105-109. DOI: https://doi.org/10.1002/jja2.12971.
  15. Yuta Yokokawa, Rieko Sakurai, Daisuke Kudo, Gen Tamiya, Shigeki Kushimoto. Clinical subphenotypes of sepsis based on mixed continuous and categorical data and differences in treatment effects: A cluster analysis of multicenter observational studies. Crit Care 2026 Jan 15;30(1):28. doi: 10.1186/s13054-025-05819-4. DOI: https://doi.org/10.21203/rs.3.rs-7716199/v1
  16. Hiroyuki Ohbe, Yusuke Sasabuchi, Yuya Kimura, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Daisuke Kudo Predictors of and Hospital-Level Variation in Intensive Care Unit Readmissions in Japan: A Nationwide Inpatient Database Study. J Intensive Care 2025 Nov 29;14(1):2. doi: 10.1186/s40560-025-00838-3.
  17. Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta, Takuya Kimura, Yukitoshi Toyoda, Michihito Kyo, Tetsuya Sato, Masashi Kinjo, Masaki Takahashi, Junichi Maruyama, Hiroshi Matsuura, Kazunori Fukushima, Takeshi Morimoto on behalf of BEAT-SHOCK Registry Investigator. Ultra-Long Polymyxin B Hemoperfusion and Its Effect onVasopressor Dosage and Organ Dysfunction in PatientsWith Septic Shock Requiring High-Dose Norepinephrine: A Post Hoc Analysis of a Prospective Cohort Study. Artificial organs. First published: 09 October 2025 https://doi.org/10.1111/aor.70025
  18. Keisuke Suzuki, Akira Endo, Tomohiro Akutsu, Hiromasa Hoshi, Takayuki Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Tasuku Miyake, Nao Hiroe, Kazushige Inoue, Toru Hifumi, Takahito Miyake, Ayaka Matsuoka, Wataru Takayama, Hiromichi Naito, Taeko Sasaki, Motoo Fujita, Keita Miyazaki, Noritaka Ushio, Yuki Saoyama, Kazutaka Kirizume, Atsuyoshi Iida, Yuya Yoshimura, Takeshi Wada, Kohei Kato, Koichiro Sueyoshi, Mitsuhide Hamaguchi, Tadashi Kaneko, Koji Morishita. External validation of the revised lethal triad criteria for appropriate strategic decision making. J Trauma Acute Care Surg 2026 Jan 1;100(1):113-118. doi: 10.1097/TA.0000000000004782.
  19. Yuko Okishio, Kyohei Miyamoto, Tsuyoshi Nakashima, Mineji Hayakawa, Daisuke Kudo, Shigeki Kushimoto, Takashi Tagami, Kosei Kunitatsu, Shuji Kawashima, Kentaro Ueda, Shigeaki Inoue. Association between anemia and trauma-related severe acute kidney injury in trauma patients at risk of major bleeding: A post-hoc analysis of the RESTRIC trial. Journal of Critical Care 2026:92:155364. doi: 10.1016/j.jcrc.2025.155364.
  20. Hiroki Fukuhara ,Osamu Ichiyanagi , Asumi Sugiura ,Yuko Kawamura ,Shinichi Midorikawa ,Tadahiro Kobayashi ,Tadahiro Kaneko ,Masaaki Tsukigi, Ryosuke Nomura ,Masaki Ushijima ,Kazunori Takahashi ,Kento Morozumi ,Keiji Inoue , Tomoyuki Endo ,Norihiko Tsuchiya ,CHOKAI Study Group. Head-to-head comparison of the CHOKAI and UROLITHIASIS scores for predicting ureteral stones: A multicenter prospective validation. The American Journal of Emergency Medicine. Am J Emerg Med Volume 100, February 2026, Pages 39-45. 2025 Nov 15:100:39-45. doi: 10.1016/j.ajem.2025.11.016.
  21. Hiroyuki Ohbe, Daisuke Kudo, Yuya Kimura, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Shigeki Kushimoto. Outcome, Process, Utilization, and Cost Measurements of Patients Admitted to the ICU in Hospitals With Vs. Without an Intermediate Care Unit: A Nationwide Inpatient Database Study. Critical Care Medicine2026 Feb 1;54(2):234-245. doi:10.1097/CCM.0000000000006962. Epub 2025 Nov 11.
  22. Yu Kawazoe, Kyohei Miyamoto , Noriko Miyagawa , Yoshinori Ohta, Hitoshi Yamamura, Takuya Kimura, Yukitoshi Toyoda, Michihito Kyo, Tetsuya Sato, Masashi Kinjo, Masaki Takahashi, Junichi Maruyama, Kazunori Fukushima, Hiroshi Matsuura, Satoru Murata, Tomoya Okazaki, Toshihiro Sakurai, Tsuyoshi Suzuki, Tasuku Hanajima, Gaku Takahashi, Takeshi Morimoto. Polymyxin B Hemoperfusion for Patients With Septic Shock Requiring High-Dose Norepinephrine: A Multicenter Prospective Cohort Study. Critical Care Explorations 2025 Sep 22;7(10):e1320. doi: 10.1097/CCE.0000000000001320. eCollection 2025 Oct 1.
  23. Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta, Takuya Kimura, Yukitoshi Toyoda, Michihito Kyo, Tetsuya Sato, Masashi Kinjo, Masaki Takahashi, Junichi Maruyama, Hiroshi Matsuura, Kazunori Fukushima, Satoru Murata, Tomoya Okazaki, Tsuyoshi Suzuki, Toshihiro Sakurai, Gaku Takahashi, Tasuku Hanajima, Takeshi Morimoto. HEMODYNAMIC RESPONSE BY POLYMYXIN B HEMOPERFUSION AND ITS CLINICAL OUTCOMES IN PATIENTS WITH REFRACTORY SEPTIC SHOCK: A POST-HOC SUBANALYSIS OF PROSPECTIVE COHORT STUDY. Shock 2025 Oct 1;64(4):397-404. doi: 10.1097/SHK.0000000000002654. Epub 2025 Jun 17.
  24. Hiroyuki Ohbe, Daisuke Kudo, Yuya Kimura, Hiroki Matsui, Hideo Yasunaga, Shigeki Kushimoto. In-hospital mortality of patients admitted to the intermediate care unit in hospitals with and without an intensive care unit: a nationwide inpatient database study. Crit Care 2025 Jan 20;29(1):34. doi: 10.1186/s13054-025-05275-0.
  25. Hidemasa Kudo, Hiroyuki Ohbe, Kyoko Yokokawa, Yuta Yokokawa, Takashi Nakata, Atsushi Tanikawa, Tetsuya Sato, Takeaki Sato, Daisuke Kudo, Shigeki Kushimoto. Association Between Intraosseous Access Establishment and Prehospital Vasopressor Administration in Patients with Out-of-Hospital Cardiac Arrest in Helicopter Emergency Medical Services: Analysis of the Japanese Society for Aeromedical Services Registry. Air Medical Journal 2025 Sep-Oct;44(5):399-403
  26. Shuhei Takauji, Mineji Hayakawa, Shoji Yokobori, Hitoshi Kano, Keiki Shimizu, Yuichi Horikoshi, Junya Shimazaki, Jotaro Tachino, Akihiko Inoue, Taiki Moriyama, Hirotaka Sawano, Hidetada Fukushima, Kana Sugiyama1, Daiki Sunada, Takashi Toyohara, Keigo Sawamoto, Shutaro Isokawa, Miki Morikawa, Ginga Suzuki, Noriyuki Omura, Kazunari Takeda1, Tomohiro Inoue, Tian Tian, Fumiko Nakamura, Yoshihiro Nakamura, Yukitoshi Toyoda, Akihito Tampo, Yoshihiro Hagiwara, Daisuke Kudo, Norihiro Miyasaka, Tomohiro Morito, Makoto Kobayashi, Kazuto Ohtaka, Yusuke Watanabe, Tsuyoshi Maekawa, Takeshi Wada, study group ICE-CRASH II. Intensive care with endovascular catheter rewarming for accidental severe hypothermia (ICE-CRASH Ⅱ): A protocol for a randomized controlled study. BMJ Open 2025 Sep 16;15(9):e104625. doi: 10.1136/bmjopen-2025-104625.
  27. Atsushi Tanikawa, Daisuke Kudo, Hiroyuki Ohbe, Morihiro Katsura, Katsunori Ono, Yohei Inaba, Shigeki Kushimoto. CT radiation exposure and management of delayed pseudoaneurysms in pediatric liver and spleen injuries: A multicenter study. Acute Medicine & Surgery 2025 Sep 24;12(1):e70089. doi: 10.1002/ams2.70089
  28. Fumito Saijo, Yutaro Arata, Naoya Akazawa, Sota Oguro, Daisuke Konno, Ami Sato, Kaoru Sato, Kentaro Sawada, Rie Tanaka, Atsushi Mitamura, Norihiro Miyasaka, Mitsuhisa Mutoh, Yoshikazu Muroya, Shingo Tsujinaka, Kei Omata, Naoto Tamagake, Yuta Yokokawa, Takeshi Aoki, Shingo Toyama, and Shinichi Egawa. Evaluation of a novel standardized education program for centrally inserted central catheters insertion in a region of Japan. The Journal of Vascular Access. 2025 Sep 19:11297298251371750 doi: 10.1177/11297298251371750
  29. Yukiko Asanuma, Motoo Fujita, Tomomi Sato, Takuma Sato and Shigeki Kushimoto. Isolated renal pelvis rupture due to blunt trauma presenting with low-density fluid accumulation around kidney on initial CT: A case report. Trauma Case Reports 2025 Jul 9:58:101220. https://doi.org/10.1016/j.tcr.2025.101220
  30. Hiroyuki Ohbe, Daisuke Kudo, Naoya Kobayashi, Kasumi Shirasaki, Kensuke Nakamura, Theodore J Iwashyna, Shigeki Kushimoto. Timing of onset of persistent critical illness in Japan: a nationwide registry study. Lancet Reg Health West Pac. 2025 Jul 9:60:101632. doi:10.1016/j.lanwpc.2025.101632. eCollection 2025 Jul.
  31. Sato Takeaki. Probiotic treatment in an intensive care unit: a narrative review. J Intensive Care 2025 Jun 5;13(1):31 https://doi.org/10.1186/s40560-025-00803-0
  32. Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yuta Yokokawa, et al. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med 2025 May;51(5):883-892. doi: 10.1007/s00134-025-07910-4. Epub 2025 May 13.
  33. Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta, Takuya Kimura, Yukitoshi Toyoda, Michihito Kyo, Tetsuya Sato, Masashi Kinjo, Masaki Takahashi, Junichi Maruyama, Hiroshi Matsuura, Kazunori Fukushima, Satoru Murata, Tomoya Okazaki, Tsuyoshi Suzuki, Toshihiro Sakurai, Gaku Takahashi, Tasuku Hanajima and Takeshi Morimoto. Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study. Crit Care. 2025 May 9;29(1):187. https://doi.org/10.1186/s13054-025-05422-7
  34. Hiroyuki Ohbe*, Kazuma Yamakawa, Daisuke Kudo, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Tomoaki Yatabe, Moritoki Egi, Hiroshi Ogura, Osamu Nishida and Shigeki Kushimoto. Impact of the Japanese clinical practice guidelines for management of sepsis and septic shock (J-SSCG) 2020 on real-world adherence and interhospital variation: a nationwide inpatient database study. Crit Care 2025 Jun 3;29(1):225. DOI：10.1186/s13054-025-05482-9. (2025/6/3)
  35. Yuki Takahashi, Mineji Hayakawa, Yuki Itagaki, Kota Ono, Daisuke Kudo, Shigeki Kushimoto. Coagulopathy as a predictor of the effectiveness of tranexamic acid in severe blunt trauma: a multicenter retrospective study. Thromb J 2025 Apr 22;23(1):37. https://doi.org/10.1186/s12959-025-00723-x.
  36. 工藤大介, 久志本成樹. 私の治療 高山病. 日本医事新報 2025;5270:36-38

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