東北大学病院高度救命救急センター|東北大学大学院医学系研究科 外科病態学講座
救急医学分野
診療・研究実績
2024年の業績
論文
- Tetsuro Kimura, Redi Rahmani, Takeshi Miyamoto, Yoshinobu Kami, Daisuke Kudo,
Hiroki Sato, Taichi Ikedo, Jacob F. Baranoski, Hiroki Uchikawa, Jinglu Ai, Michael T, Lawton, Tomoki Hashimoto. Vitamin D Deficiency Promotes Intracranial Aneurysm Rupture. Journal of Cerebral Blood Flow and Metabolism. in press.
- Taichi Ishiguro, Hajime Furukawa, Kyle Polen, Yushiro Take, Hiroki Sato, Daisuke Kudo,
Jordan Morgan, Hiroki Uchikawa, Takuma Maeda, Oscar Cisneros, Redi Rahmani, Jinglu Ai, Satoru Eguchi, Michael Lawton, and Tomoki Hashimoto. Pharmacological inhibition of epidermal growth factor receptor prevents intracranial aneurysm rupture by reducing endoplasmic reticulum stress. Hypertension 2024 in press.
- Ohbe, H., Hashimoto, S., Ogura, T. et al. Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study. j intensive care 12, 6 (2024).
https://doi.org/10.1186/s40560-024-00718-2
- Nishikimi M, Ohshimo S, Fukumoto W, Hamaguchi J, Matsumura K, Fujizuka K, Hagiwara Y, Nakayama R, Bunya N, Maruyama J, Abe T, Anzai T, Ogata Y, Naito H, Amemiya Y, Ikeda T, Yagi M, Furukawa Y, Taniguchi H, Yagi T, Katsuta K, Konno D, Suzuki G, Kawasaki Y, Hattori N, Nakamura T, Kondo N, Kikuchi H, Kai S, Ichiyama S, Awai K, Takahashi K, Shime N; J-CARVE registry group. Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry. J Intensive Care. 2024 Jan 26;12(1):5. doi: 10.1186/s40560-023-00715-x. PMID: 38273416; PMCID: PMC10811928.
- Yasaka M, Suzuki M, Kushimoto S, Kiyonaga A, Mangione A, Niwa Y, Terasaka N. Real-World Safety and Effectiveness of a 4-Factor Prothrombin Complex Concentrate in Japanese Patients Experiencing Major Bleeding: A Post-marketing Surveillance Study. Cardiol Ther. 2024 Feb 6.
doi: 10.1007/s40119-024-00357-6. Epub ahead of print. PMID: 38319533.
- 工藤大介、久志本成樹. 敗血症診療ガイドライン2020 DICの診断と治療:ヘパリン・ヘパリン類.
Thrombosis Medicine 2024;14(1): 52-56
- Hiroyuki Ohbe; Satoru Hashimoto; Takayuki Ogura; Mitsuaki Nishikimi;Daisuke Kudo;
Nobuaki Shime; Shigeki Kushimoto
Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: A population-based cohort study.
- Yamakawa K, Umemura Y, Mochizuki K, Matsuoka T, Wada T, Hayakawa M, Iba T, Ohtomo Y, Okamoto K, Mayumi T, Ikeda T, Ishikura H, Ogura H, Kushimoto S, Saitoh D, Gando S. Proposal and Validation of a Clinically
Relevant Modification of the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Diagnostic Criteria for Sepsis.Thromb Haemost. 2024 May 10.
doi: 10.1055/s-0044-1786808. Epub ahead of print. PMID: 38729189.
- Ohbe H, Hashimoto S, Ogura T, Nishikimi M, Kudo D, Shime N, Kushimoto S. Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study. J Intensive Care. 2024
Jan 30;12(1):6.
doi: 10.1186/s40560-024-00718-2. PMID: 38287432; PMCID: PMC10826037.
- Kosaki Y, Hongo T, Hayakawa M, Kudo D, Kushimoto S, Tagami T, Naito H, Nakao A, Yumoto T. Association of initial lactate levels and red blood cell transfusion strategy with outcomes after severe trauma: a post hoc analysis of the RESTRIC trial. World J Emerg Surg.
2024 Jan 2;19(1):1.doi: 10.1186/s13017-023-00530-7. PMID: 38167057; PMCID: PMC10763143.
- "Development and validation of early prediction models for new-onset functional impairment of patients with trauma at hospital discharge"
- 久志本成樹, 角田拓也. 救急患者はどのように診療する?―基本的コンセプトと実践的アプローチ―. 臨床と研究 2024; 101: 524-527.
- Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of a multi-center prospective cohort study
Kosuke Shoji; Hiroyuki Ohbe; Tasuku Matsuyama; Akihiko Inoue; Toru; Hifumi; Tetsuya Sakamoto; Yasuhiro Kuroda; Shigeki Kushimoto; the SAVE-JII study group
- Hospital and regional variations in intensive care unit admission for patients with invasive
mechanical ventilation
Hiroyuki Ohbe; Nobuaki Shime; Hayato Yamana; Tadahiro Goto; Yusuke Sasabuchi;
Daisuke Kudo; Hiroki Matsui; Hideo Yasunaga; Shigeki Kushimoto Journal of Intensive Care
- 久志本成樹. ワルファリンの中和:プロトロンビン複合体製剤. 臨床に直結する血栓止血学改訂
第3版. 朝倉英策 編. 中外医学社, 東京. 2024, pp530-534.
- 久志本成樹. Open abdomen management を知らずに重症外傷患者の“腹”を診療できるか !.
日外傷会誌 2024;38(3): 353-359.
- Abe T, Umemura Y, Ogura H, Kushimoto S, Fujishima S, Shiraishi A, Saitoh D, Mayumi T, Otomo Y, Nakada T, Gando S. Relationship Between Fluid Administration During the First Three Hours of Sepsis Resuscitation and Mortality: A Multicenter Observational Study. Cureus 16(7): e65480. doi:10.7759/cureus.65480
- Ohbe H, Yokokawa Y, Sato T, Kudo D, Kushimoto S. Development and validation of early prediction models for new-onset functional impairment of patients with trauma at hospital discharge. J Trauma Acute Care Surg. 2024 Jul 30. doi: 10.1097/TA.0000000000004420. Epub ahead of print. PMID: 39075635.
- Shoji K, Ohbe H, Matsuyama T, Inoue A, Hifumi T, Sakamoto T, Kuroda Y, Kushimoto S; SAVE-J II study group. Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study. J Intensive Care. 2024 Jun 11;12(1):22. doi: 10.1186/s40560-024-00735-1. PMID: 38863061; PMCID: PMC11165865.
- Yamamoto R, Kaito D, Homma K, Inoue A, Hifumi T, Sakamoto T, Kuroda Y, Sasaki J; SAVE‐
J II study group *. Door-to-Needle Time for Extracorporeal Cardiopulmonary Resuscitation and Neurological Outcomes in Out-of-Hospital Cardiac Arrest: A Nationwide Study. J Am Heart Assoc. 2024 Jun 18;13(12):e034971. doi: 10.1161/JAHA.124.034971. Epub 2024 Jun 6. PMID: 38842281; PMCID: PMC11255735.
- Ohbe H, Shime N, Yamana H, Goto T, Sasabuchi Y, Kudo D, Matsui H, Yasunaga H,
Kushimoto S. Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation. J Intensive Care. 2024 Jun 5;12(1):21. doi: 10.1186/s40560-024-00736-0. PMID: 38840225; PMCID: PMC11155017.
- Yamamoto R, Sato Y, Cestero RF, Eastridge BJ, Maeshima K, Katsura M, Kondo Y, Yasuda H, Kushimoto S, Sasaki J. Follow-up computed tomography and unexpected hemostasis in non-operative management of pediatric blunt liver and spleen injury. Eur J Trauma Emerg Surg. 2024 May 23. doi: 10.1007/s00068-024-02540-9. Epub ahead of print. PMID: 38780783.
- Takiguchi T, Tominaga N, Hamaguchi T, Seki T, Nakata J, Yamamoto T, Tagami T, Inoue A, Hifumi T, Sakamoto T, Kuroda Y, Yokobori S; SAVE-J II Study Group. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study. Chest. 2024 Apr;165(4):858-869. doi: 10.1016/j.chest.2023.10.022. Epub 2023 Oct 23. PMID: 37879561.
- Ito Y, Kudo D, Fujita M, Osawa S- ichiro, Nakagawa A, Kushimoto S. Acute Ischemic Stroke Therapy in a Hybrid Emergency Room: An Institutional Observational Cohort Study. JEVTM [Internet]. 2023 Jan. 31 [cited 2024 Sep. 1];6(3):121-6. Available from: https://publicera.kb.se/jevtm/article/view/16474
- Characteristics of bleeding complications in patients with severe COVID19 requiring
veno-venous extracorporeal membrane oxygenation in Japan
Hayato Taniguchi 1, Takeru Abe 1, Ichiro Takeuchi 1, Shinichiro Ohshimo 2, Nobuaki Shime 2, Shigeki Kushimoto 3, Satoru Hashimoto 4, Shinhiro Takeda 5
Affiliations Expand PMID: 39242097 DOI: 10.1055/a-2411-1000
- Effects of hybrid emergency room on extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients
- "Adherence to balanced transfusion among severely injured patients: a post hoc analysis of the RESTRIC trial"
- Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study.
Kazuya Kikutani; Mitsuaki Nishikimi; Ryo Emoto; Shigeyuki Matsui; Hiroyuki Ohbe; Takayuki Ogura; Satoru Hashimoto; Shigeki Kushimoto; Shinhiro Takeda; Shinichiro Ohshimo; Nobuaki Shime
- Title: Plasma high-mobility group box-1 and galectin-9 in patients with trauma and their prognostic potentials
- Time Trends of Outcome and Treatment Options for Disseminated Intravascular Coagulation from 2010 to 2021 in Japan: A Nationwide Observational Study
- Reply to the comment by Sakamoto et al. on “The method to identify invasive mechanical ventilation with Japanese claim data”
Hiroyuki Ohbe; Nobuaki Shime; Hayato Yamana; Tadahiro Goto; Yusuke Sasabuchi; Daisuke Kudo; Hiroki Matsui; Hideo Yasunaga; Shigeki Kushimoto
Journal of Intensive Care
- 横山龍人、工藤大介、中田貴史、水戸部慶彦、久志本成樹. COVID-19を契機に発症したと考えられるシェーグレン症候群に伴う尿細管性アシドーシスの1例
- "In-hospital mortality of patients admitted to the intermediate care unit in hospitals with and without an intensive care unit: a nationwide inpatient database study"
- 工藤 大介、後藤 匡啓、大沢 樹輝、久志本 成樹
敗血症サブクラス分類による治療戦略:抗凝固薬による治療の可能性
Shock 2024; 38(2): 20-26
- 池田 弘人, 青木 大, 伊東 大, 織田 順, 片平 次郎, 久志本 成樹, 島田 賢一, 鳴海 篤志, 福島 英賢, 松村 一, 田中 秀治, 副島 一孝, 佐々木 淳一. 広範囲重症熱傷に対する凍結同種皮膚移植術のための安定したAllograftの供給に関する研究. 熱傷 2024: 50; 145-149.
- 工藤 大介, 久志本 成樹, DICを伴う敗血症患者に対する抗凝固療法におけるAIの活用, 臨床血液, 2024: 65; 1125-1130. (Kudo D, Kushimoto S. [AI for anticoagulant therapy for patients with sepsis-induced DIC: issues and future direction of identifying sepsis subclass]. Rinsho Ketsueki. 2024;65(9):1125-1130. Japanese. doi: 10.11406/rinketsu.65.1125. PMID: 39358269.)
- Nakata T, Kudo D, Kudo Y, Tanikawa A, Katsuta K, Ohbe H, Kobayashi M, Suda A, Yasuda S, Kushimoto S. Effects of hybrid emergency department on extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients. Resusc Plus. 2024 Sep 5;20:100764. doi: 10.1016/j.resplu.2024.100764. PMID: 39296345; PMCID: PMC11408869.
- Taniguchi H, Abe T, Takeuchi I, Ohshimo S, Shime N, Kushimoto S, Hashimoto S, Takeda S; Japan ECMO Network. Characteristics of Bleeding Complications in Patients with Severe COVID-19 Requiring Veno-venous Extracorporeal Membrane Oxygenation in Japan. Thromb Haemost. 2024 Sep 27. doi: 10.1055/a-2411-1000. Epub ahead of print. PMID: 39242097.
- 工藤 大介、久志本成樹. 敗血症におけるフェノタイプ分類の現状と展望.
ICUとCCU 2024; 48(11): 643-649
- Niki T, Chagan-Yasutan H, Furushima D, Hattori T, Ashino Y, Yamanouchi S, Kushimoto S. Plasma High-Mobility Group Box-1 and Galectin-9 in Patients with Trauma and Their Prognostic Potentials. Tohoku J Exp Med. 2024 Nov 7. doi: 10.1620/tjem.2024.J130. Epub ahead of print. PMID: 39505526.
- Aoki M, Fukushima K, Hayakawa M, Kudo D, Tagami T, Oshima K, Kushimoto S. Adherence to balanced transfusion among severely injured patients: A post hoc analysis of the RESTRIC trial. Acute Med Surg. 2024 Nov 5;11(1):e70016. doi: 10.1002/ams2.70016. PMID: 39503015; PMCID: PMC11536327.
- Kikutani K, Nishikimi M, Emoto R, Matsui S, Ohbe H, Ogura T, Hashimoto S, Kushimoto S, Takeda S, Ohshimo S, Shime N. Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study. J Intensive Care. 2024 Nov 5;12(1):46. doi: 10.1186/s40560-024-00758-8. PMID: 39501345; PMCID: PMC11536903.
- 前澤翔太, 久志本成樹. 大量出血: 外傷. 大量輸血プロトコルを軸とした重要外傷患者への輸血戦略. Hospitalist. 2024;12:143-150.
- Yamakawa K, Okamoto K, Seki Y, Ikezoe T, Ito T, Iba T, Gando S, Ushio N, Totoki T, Wada T, Asakura H, Ishikura H, Uchiba M, Uchiyama T, Kawasaki K, Kawano N, Kushimoto S, Koga S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Madoiwa S, Mayumi T, Yamada S, Wada H; Committee of the Clinical Practice Guidelines for Management of Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis. Int J Hematol. 2024 Dec 16. doi: 10.1007/s12185-024-03896-9. Epub ahead of print. PMID: 39676120.
- Kawano N, Ikezoe T, Seki Y, Yamakawa K, Okamoto K, Fukatsu M, Madoiwa S, Uchiyama T, Asakura H, Yamada S, Koga S, Ishikura H, Ito T, Iba T, Uchiba M, Kawasaki K, Gando S, Kushimoto S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Mayumi T, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 2: hematologic malignancy. Int J Hematol. 2024 Dec 15. doi: 10.1007/s12185-024-03887-w. Epub ahead of print. PMID: 39674834.
- Itagaki Y, Hayakawa M, Takahashi Y, Sakamoto Y, Kushimoto S, Eguchi Y, Seki Y, Okamoto K. The efficacy of coagulation factor concentrates in the management of patients with trauma-induced coagulopathy: a systematic review and meta-analysis.
- Ohbe, H., Shime, N., Yamana, H. et al. Reply to the comment by Sakamoto et al. on “The method to identify invasive mechanical ventilation with Japanese claim data”. j intensive care 12, 54 (2024). https://doi.org/10.1186/s40560-024-00767-7
- Ohbe H, Satoh K, Totoki T, Tanikawa A, Shirasaki K, Kuribayashi Y, Tamura M, Takatani Y, Ishikura H, Nakamura K; J-STAD (JAPAN Sepsis Treatment and Diagnosis) Study Group. Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice. Crit Care. 2024 Dec 28;28(1):435. doi: 10.1186/s13054-024-05215-4. PMID: 39731183; PMCID: PMC11681689.
- Shimada Y, Ohbe H, Kutsuna S, Kosaka S, Matsui H, Yasunaga H. Effect of Empirical Antimicrobial Therapy of Piperacillin-tazobactam Versus Carbapenems on Mortality for Patients with Sepsis from Nursing Homes. Intern Med. 2024 Nov 21. doi: 10.2169/internalmedicine.4426-24. Epub ahead of print. PMID: 39566987.
- Kamijo K, Nakajima M, Shigemi D, Kaszynski RH, Ohbe H, Goto T, Sasabuchi Y, Fushimi K, Matsui H, Yasunaga H. Characteristics and outcomes of patients with postpartum hemorrhage undergoing transcatheter arterial embolization: A nationwide observational study. Int J Gynaecol Obstet. 2024 Nov 18. doi: 10.1002/ijgo.16040. Epub ahead of print. PMID: 39552524.
- Yamamoto R, Sato Y, Maeshima K, Tomita K, Takemura R, Katsura M, Kondo Y, Yasuda H, Kushimoto S, Sasaki J. Pediatric blunt liver and spleen injury treated in hospitals with pediatric intensive care units: Post-hoc analysis of a multicenter, retrospective observational study. J Pediatr Surg. 2024 Dec 16;60(3):162106. doi: 10.1016/j.jpedsurg.2024.162106. Epub ahead of print. PMID: 39733604.
- Seki Y, Okamoto K, Ikezoe T, Yamakawa K, Madoiwa S, Uchiyama T, Asakura H, Yamada S, Koga S, Ishikura H, Ito T, Iba T, Uchiba M, Kawasaki K, Kawano N, Gando S, Kushimoto S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Mayumi T, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 3: solid cancers and vascular abnormalities. Int J Hematol. 2025 Jan 10. doi: 10.1007/s12185-024-03912-y. Epub ahead of print. PMID: 39792236.
